Ctcf p53
WebKey words: CTCF, p53, breast cancer Introduction CCCTC-binding factor (CTCF) is a widely expressed 11-zinc finger multifunctional protein that is involved in different aspects of gene regulation including promoter activation or repression, chromatin insulation, and genomic imprinting [1]. The suggestive role of CTCF in cancer tumorigenesis WebApr 1, 2014 · CTCF regulates p53 expression by physically interacting with Wrap53 RNA, which is the natural antisense transcript of p53. Deletion of CTCF not only resulted in a …
Ctcf p53
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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture. WebOct 1, 2001 · indirect 21 or direct 37 CTCF–p53 interactions. A third motif of potential importance, located. between the A T-hook and phosphorylation sites (Fig. 1c), contains two repeats of the PXXP-signature.
WebFigure 1. CTCF is required for regulation of the p53/Wrap53 locus. (A) Genomic organization of the p53/Wrap53 locus.(B) Immunoblot after shRNA-mediated knockdown … WebJustia US Law US Codes and Statutes Connecticut Code 2005 Connecticut Code Title 53a — Penal Code (contains Chapters 950 to 952) Chapter 952 — Penal Code: Offenses …
http://genesdev.cshlp.org/content/28/7/723.full#:~:text=Apart%20from%20its%20established%20role%20at%20the%20p53,exhibit%20a%20defective%20p53%20response%20to%20DNA%20damage. Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more
WebNov 25, 2024 · By integrating transcriptome, regulatory element and chromosome topology profiles, Schwartz et al identify redistribution of p53 and CTCF genomic binding to be associated with transcriptional and ...
WebNov 8, 2010 · Thus, the suppressive effect of p53 on BORIS isoforms may be due, at least in part, to upregulation of CTCF . In summary, p53 effects, CTCF binding, and DNA methylation provide three interdependent mechanisms for the complete suppression of BORIS isoforms expression in somatic cells, as a means of avoiding BORIS competition … daltons banana guesthouseWebOct 5, 2024 · Although according to some reports, repressive effects of CTCF, p53, and promoter DNA methylation has restricted the expression of BORIS to testicular germ cells [1, 7, 11, 13, 15, 24, 25, 28], a few other studies have shown that in addition to male germ cells, BORIS transcripts are also expressed in other normal tissues such as human … daltons atomhypotheseWebJun 28, 2024 · The association of CTCF binding with RNAPII stalling at specific sites has been previously observed genome-wide in multiple cell lines , particularly at CTCF sites … bird eater tarantulas for saleWebApr 17, 2014 · CTCF is known to bind to and induce the transcription of TP53, and the CTCF binding site in the TP53 promoter overlaps with the first intron of WRAP53 on the opposite DNA strand, suggesting that ... daltons chicken moultrieWebApr 7, 2024 · The use of next-generation sequencing demonstrated that the most prevalent genomic alterations in patients with endometrioid ovarian carcinoma include ARID1A, PIK3CA, PTEN, CTNNB1, KRAS, and P53. birdeater spider picsWebNov 25, 2024 · Using Hi-C data, we observe spatial coupling between differentially expressed genes and their differentially accessible regulatory elements and reveal two … bird eater tarantulas sizedaltons chemist cork